Abstract
The discovery of antibiotics opened a new era in the treatment against several pathogenic microorganisms that can disable or kill humans. The appearance of the fluoroquinolones (based on nalidixic acid, 4-quinolone-3-carboxylates), in the early 1980s, gave a new impetus in the treatment of infectious diseases. Despite these favourable properties, the earlier fluoroquinolones had limited potency against some clinically important organisms, especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem. Thus the development of new fluoroquinolones with a better pharmacokinetic profile, potency, broad spectrum of activity, solubility, prolonged serum half-life and oral and parenteral routes of administration has been a major focus on recent research. The increasing interest in this class led me to review the promising new fluoroquinolones in clinical trials.
Keywords: fluoroquinolones, fluorine, microbiological activity, antibiotics
Mini-Reviews in Medicinal Chemistry
Title: New Fluoroquinolones: A Class of Potent Antibiotics
Volume: 5 Issue: 11
Author(s): Marcus V. N. De Souza
Affiliation:
Keywords: fluoroquinolones, fluorine, microbiological activity, antibiotics
Abstract: The discovery of antibiotics opened a new era in the treatment against several pathogenic microorganisms that can disable or kill humans. The appearance of the fluoroquinolones (based on nalidixic acid, 4-quinolone-3-carboxylates), in the early 1980s, gave a new impetus in the treatment of infectious diseases. Despite these favourable properties, the earlier fluoroquinolones had limited potency against some clinically important organisms, especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem. Thus the development of new fluoroquinolones with a better pharmacokinetic profile, potency, broad spectrum of activity, solubility, prolonged serum half-life and oral and parenteral routes of administration has been a major focus on recent research. The increasing interest in this class led me to review the promising new fluoroquinolones in clinical trials.
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Cite this article as:
De Souza V. N. Marcus, New Fluoroquinolones: A Class of Potent Antibiotics, Mini-Reviews in Medicinal Chemistry 2005; 5 (11) . https://dx.doi.org/10.2174/138955705774575246
DOI https://dx.doi.org/10.2174/138955705774575246 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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