Anti-tumour Activity of Some Polydentate N-Ligands: N,N-bis-(3- Substituted-5-Methylpyrazol-1yl Methyl) Arylamines and N,N,N,N-Tetra- [(3-Substituted-5-Methylpyrazol-1yl] Para-Phenylenediamines

Title: Anti-tumour Activity of Some Polydentate N-Ligands: N,N-bis-(3- Substituted-5-Methylpyrazol-1yl Methyl) Arylamines and N,N,N,N-Tetra- [(3-Substituted-5-Methylpyrazol-1yl] Para-Phenylenediamines

Volume: 2 Issue: 8

Author(s): T. B. Hadda, A. T. Kotchevar, M. Daoudi, B. Bennani, N. B. Larbi and A. Kerbal

Affiliation:

Keywords: Polydentate N-ligands, pyrazole, cytotoxicity, cancer

Abstract: Five polydentate ligands 2-6 were prepared from arylamines and precursors 1a-b. The polydentate (2-4) and (5) showed marked activity against cancer cell lines. The substituents (R and R) appear to play a key role in the cytotoxic potency of this class of compounds.

Cite this article as:

Hadda B. T., Kotchevar T. A., Daoudi M., Bennani B., Larbi B. N. and Kerbal A., Anti-tumour Activity of Some Polydentate N-Ligands: N,N-bis-(3- Substituted-5-Methylpyrazol-1yl Methyl) Arylamines and N,N,N,N-Tetra- [(3-Substituted-5-Methylpyrazol-1yl] Para-Phenylenediamines, Letters in Drug Design & Discovery 2005; 2 (8) . https://dx.doi.org/10.2174/157018005774717299