Structure-Function Relationships in Serine Protease-Bovine Pancreatic Trypsin Inhibitor Interaction

Title: Structure-Function Relationships in Serine Protease-Bovine Pancreatic Trypsin Inhibitor Interaction

Volume: 12 Issue: 5

Author(s): D. Krowarsch, M. Zakrzewska, A. O. Smalas and J. Otlewski

Affiliation:

Keywords: protein-protein recognition, serine protease, canonical protein inhibitor, protein stability

Abstract: We report our progress in understanding the structure-function relationships for the interaction between BPTI and serine proteases. We focused on extensive mutagenesis of four crucial positions from the protease binding loop of BPTI. Selected variants were characterized by determination of association constants, stability parameters and structures of protease-inhibitor complexes.

Cite this article as:

Krowarsch D., Zakrzewska M., Smalas O. A. and Otlewski J., Structure-Function Relationships in Serine Protease-Bovine Pancreatic Trypsin Inhibitor Interaction, Protein & Peptide Letters 2005; 12 (5) . https://dx.doi.org/10.2174/0929866054395275