Highlights in Organic Chemistry [Modification of Nucleoside Heterocycles to Probe and Expand Nucleic Acid Structure and Function]

Title: Highlights in Organic Chemistry [Modification of Nucleoside Heterocycles to Probe and Expand Nucleic Acid Structure and Function]

Volume: 2 Issue: 6

Author(s): E. Rozners

Affiliation:

Keywords: dna, heterocyclic bases, watson-crick-like hydrogen-bonding, epimerization, hybridization, nucleobases, hydrophobic base

Abstract: Recent progress in molecular biology and genetics has invigorated interest in modified nucleic acids both for fundamental studies and for practical applications. Herein, recent advances in design of modified non- Watson-Crick base pairs are highlighted. Examples of altered hydrogen-bonding patterns, size-expanded bases, and base pairing dependent on metal chelation and hydrophobic interactions are discussed.

Cite this article as:

Rozners E., Highlights in Organic Chemistry [Modification of Nucleoside Heterocycles to Probe and Expand Nucleic Acid Structure and Function], Letters in Organic Chemistry 2005; 2 (6) . https://dx.doi.org/10.2174/1570178054640714