Chemical Synthesis Approaches to the Engineering of Ion Channels

Title: Chemical Synthesis Approaches to the Engineering of Ion Channels

Volume: 12 Issue: 8

Author(s): Gerd G. Kochendoerfer, Daniel Clayton and Christian Becker

Affiliation:

Keywords: chemical protein synthesis, native chemical ligation, membrane proteins, ion channels, protein engineering

Abstract: Chemoselective ligation strategies have previously provided synthetic access to water-soluble proteins with novel properties, and more recently these strategies have been used to prepare ion channels. Examples of ion channels prepared by total chemical synthesis include bacterial mechanosensitive channels, and viral ion channels. Chemical protein synthesis allows for the generation of ion channel proteins with both native, and engineered structural or conductance properties.

Cite this article as:

Kochendoerfer G. Gerd, Clayton Daniel and Becker Christian, Chemical Synthesis Approaches to the Engineering of Ion Channels, Protein & Peptide Letters 2005; 12 (8) . https://dx.doi.org/10.2174/0929866054864256