Abstract
The main hypothesis for prion diseases proposes that the cellular protein (PrPC) can be altered into a misfolded, β-sheet-rich isoform (PrPSc). We describe here that host nucleic acid may catalyze the conversion between PrPC and PrPSc isoforms, by reducing the protein mobility and by making the protein-protein interactions more likely. We summarize the findings, focusing in the biological relevance of the catalytic action of nucleic acid.
Keywords: prion, structural conversion, nucleic acid, catalysis, aggregation
Protein & Peptide Letters
Title: The Hypothesis of the Catalytic Action of Nucleic Acid on the Conversion of Prion Protein
Volume: 12 Issue: 3
Author(s): Yraima Cordeiro and Jerson L. Silva
Affiliation:
Keywords: prion, structural conversion, nucleic acid, catalysis, aggregation
Abstract: The main hypothesis for prion diseases proposes that the cellular protein (PrPC) can be altered into a misfolded, β-sheet-rich isoform (PrPSc). We describe here that host nucleic acid may catalyze the conversion between PrPC and PrPSc isoforms, by reducing the protein mobility and by making the protein-protein interactions more likely. We summarize the findings, focusing in the biological relevance of the catalytic action of nucleic acid.
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Cite this article as:
Cordeiro Yraima and Silva L. Jerson, The Hypothesis of the Catalytic Action of Nucleic Acid on the Conversion of Prion Protein, Protein & Peptide Letters 2005; 12 (3) . https://dx.doi.org/10.2174/0929866053587138
DOI https://dx.doi.org/10.2174/0929866053587138 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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