Synthesis of a Spiro D-Proline Analogue Bearing D-Fructose

Title: Synthesis of a Spiro D-Proline Analogue Bearing D-Fructose

Volume: 2 Issue: 4

Author(s): Laura Cipolla, Cristina Redaelli and Francesco Nicotra

Affiliation:

Keywords: d-proline, fructose, amino acid analogue, c-glycosides

Abstract: A bicyclic spiro analogue of D-proline was synthesized from perbenzylated methyl D-fructoside. The synthetic steps required first a three carbon chain elongation at the anomeric position by C-glycosylation, secondly the introduction of the amino function at C-1, and finally the cyclization to the pyrrolidine ring and introduction of the carboxylic group.

Cite this article as:

Cipolla Laura, Redaelli Cristina and Nicotra Francesco, Synthesis of a Spiro D-Proline Analogue Bearing D-Fructose, Letters in Drug Design & Discovery 2005; 2 (4) . https://dx.doi.org/10.2174/1570180054038369