Abstract
There are many suggestions that pre-eclampsia has an immunological basis. According to the immunological theory of the disease, there is a failure of the immunological recognition of fetal alloantigens during pregnancy. It seems that abnormal activation of the immune system may play a role in the etiology of pre-eclampsia. Many authors have found a number of changes in the adaptive immune system which may contribute to the development of pre-eclampsia. Recent data suggest that pre-eclampsia is a T helper 1/T helper 2 immunity disorder with predominant Th1 type immunity. Furthermore, there is an evidence regarding the activation of the innate immune system in pre-eclampsia. It has been shown lately that normal third trimester pregnancy is characterized by the activation of peripheral blood leukocytes, which is further increased in pre-eclampsia. The possible immunological etiology of pre-eclampsia has been suggested because of some clinical and epidemiological observations. It has been observed lately that there is a protective effect of sperm exposure and that the duration of sexual cohabitation before conception is inversely related to the risk of pre-eclampsia. There are also epidemiological data that there is a higher incidence of pre-eclampsia in women conceiving by intrauterine insemination with donor sperm compared IUI with partner sperm.
Keywords: autoimmunity, cytokines, dendritic cells, hypertension in pregnancy, pre-eclampsia, lymphocytes
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RARE CASES IN GYNECOLOGY-OBSTETRICS
With the development of diagnostic and therapeutic techniques (such as ART techniques) and the immersion of new pathologies (such as COVID19), we are witnessing an increase in the incidence of pathologies that were previously described as rare or exceptional. the practitioner sometimes confronts difficult situations in these cases in diagnostic ...read more
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