Abstract
There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimers disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small shortterm studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.
Keywords: curcuma longa, liver disease, anti-oxidant, cytokines, inflammation, (nsaid), cholesterol, fibrils, pharmacokinetic, microglia
Current Alzheimer Research
Title: A Potential Role of the Curry Spice Curcumin in Alzheimers Disease
Volume: 2 Issue: 2
Author(s): John M. Ringman, Sally A. Frautschy, Gregory M. Cole, Donna L. Masterman and Jeffrey L. Cummings
Affiliation:
Keywords: curcuma longa, liver disease, anti-oxidant, cytokines, inflammation, (nsaid), cholesterol, fibrils, pharmacokinetic, microglia
Abstract: There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimers disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small shortterm studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.
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Cite this article as:
Ringman M. John, Frautschy A. Sally, Cole M. Gregory, Masterman L. Donna and Cummings L. Jeffrey, A Potential Role of the Curry Spice Curcumin in Alzheimers Disease, Current Alzheimer Research 2005; 2 (2) . https://dx.doi.org/10.2174/1567205053585882
DOI https://dx.doi.org/10.2174/1567205053585882 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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