Abstract
Vaccines should elicit protective and long lasting immune memory, which depends on well choreographed responses between innate and acquired immunity. Defensins are small host defense peptides of innate immunity hitherto reported to have antimicrobial activity, which also orchestrate chemotaxis and activation of effector immune cells, including immature dendritic cells. This review analyzes the biological meaning of the immunomodulatory and immunoenhancing features of defensins and their use for the development of novel vaccines to combat cancer and clinically relevant diseases.
Keywords: antimicrobial peptides, dendritic cells, vaccine carrier
Current Protein & Peptide Science
Title: Defensins - Non-antibiotic Use for Vaccine Development
Volume: 6 Issue: 1
Author(s): Arya Biragyn
Affiliation:
Keywords: antimicrobial peptides, dendritic cells, vaccine carrier
Abstract: Vaccines should elicit protective and long lasting immune memory, which depends on well choreographed responses between innate and acquired immunity. Defensins are small host defense peptides of innate immunity hitherto reported to have antimicrobial activity, which also orchestrate chemotaxis and activation of effector immune cells, including immature dendritic cells. This review analyzes the biological meaning of the immunomodulatory and immunoenhancing features of defensins and their use for the development of novel vaccines to combat cancer and clinically relevant diseases.
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Cite this article as:
Biragyn Arya, Defensins - Non-antibiotic Use for Vaccine Development, Current Protein & Peptide Science 2005; 6 (1) . https://dx.doi.org/10.2174/1389203053027601
DOI https://dx.doi.org/10.2174/1389203053027601 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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