Abstract
An antitumour lectin named AAL has been purified from the fruiting body of edible mushroom Agrocybe aegerita. In addition to having a distinct bioactivity, AAL shows strong inhibition effects on human and mouse tumour cells. It has been shown that AAL exerts its antitumour effects via apoptosis-induction. AAL and AAL-lactose complex have been crystallized and their diffraction data were collected with resolution of 2.6 Å and 3.0 Å, respectively. Both crystals belong to space group P 6122 with unit cell parameters a = 123.98 Å, b = 123.98 Å, c = 56.86 Å, a= b=90 , g = 120 and a = 123.69 Å, b = 123.69 Å, c = 56.64 Å, α= β=90 , γ = 120 , respectively.
Keywords: lectin, mushroom, antitumour, apoptosis, dnase activity, crystallization
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