Abstract
Virus-encoded immune evasion mechanisms provide information on viral pathogenesis and offer a unique opportunity to identify new strategies of immune modulation. Secreted proteins that bind a broad range of chemokines have been identified in recent years in poxviruses and herpesviruses. We discuss the properties of these viral chemokine inhibitors and their potential as new therapeutics to treat human inflammatory diseases.
Keywords: immune responses, immunomodulatory proteins, chemokine antagonists, myxoma virus, leporipoxvirus, recombinant protein, virus infection, bronchiolar lavage (bal)
Mini-Reviews in Medicinal Chemistry
Title: Virally Encoded Chemokine Binding Proteins
Volume: 5 Issue: 9
Author(s): Louise M.C. Webb and Antonio Alcami
Affiliation:
Keywords: immune responses, immunomodulatory proteins, chemokine antagonists, myxoma virus, leporipoxvirus, recombinant protein, virus infection, bronchiolar lavage (bal)
Abstract: Virus-encoded immune evasion mechanisms provide information on viral pathogenesis and offer a unique opportunity to identify new strategies of immune modulation. Secreted proteins that bind a broad range of chemokines have been identified in recent years in poxviruses and herpesviruses. We discuss the properties of these viral chemokine inhibitors and their potential as new therapeutics to treat human inflammatory diseases.
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Cite this article as:
Webb M.C. Louise and Alcami Antonio, Virally Encoded Chemokine Binding Proteins, Mini-Reviews in Medicinal Chemistry 2005; 5 (9) . https://dx.doi.org/10.2174/1389557054867110
DOI https://dx.doi.org/10.2174/1389557054867110 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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