Abstract
2-Phenyl-5,6-dihydroxypyrimidine-4-carboxylic acids were discovered as specific inhibitors of the NS5B polymerase of the Hepatitis C Virus. In-depth structure-activity investigations at the ortho and meta positions of the phenyl ring were undertaken, and compounds with greatly improved activity over the original lead have been discovered.
Keywords: hcv ns5b rna polymerase, dihydroxypyrimidines, sar, inhibitors, amides, ureas
Letters in Drug Design & Discovery
Title: Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas
Volume: 2 Issue: 6
Author(s): B. Crescenzi, M. Poma, J. M. Ontoria, A. Marchetti, E. Nizi, V. G. Matassa and C. Gardelli
Affiliation:
Keywords: hcv ns5b rna polymerase, dihydroxypyrimidines, sar, inhibitors, amides, ureas
Abstract: 2-Phenyl-5,6-dihydroxypyrimidine-4-carboxylic acids were discovered as specific inhibitors of the NS5B polymerase of the Hepatitis C Virus. In-depth structure-activity investigations at the ortho and meta positions of the phenyl ring were undertaken, and compounds with greatly improved activity over the original lead have been discovered.
Export Options
About this article
Cite this article as:
Crescenzi B., Poma M., Ontoria M. J., Marchetti A., Nizi E., Matassa G. V. and Gardelli C., Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas, Letters in Drug Design & Discovery 2005; 2 (6) . https://dx.doi.org/10.2174/1570180054771491
DOI https://dx.doi.org/10.2174/1570180054771491 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Colorectal Carcinogensis and Suppression of Tumor Development by Inhibition of Enzymes and Molecular Targets
Current Enzyme Inhibition Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules
Current Medicinal Chemistry Aminoglycoside Nephrotoxicity
Current Drug Targets - Infectious Disorders Structural Neuroimaging Findings in Major Depressive Disorder Throughout Aging: A Critical Systematic Review of Prospective Studies
CNS & Neurological Disorders - Drug Targets Drug Design of GPCR Ligands Using Physicogenetics and Chemogenomics - Principles and Case Studies
Current Topics in Medicinal Chemistry Ether Glycerophospholipids and Their Potential as Therapeutic Agents
Current Organic Chemistry Multiple Drug Resistance Associated with Function of ABC-Transporters in Diabetes Mellitus: Molecular Mechanism and Clinical Relevance
Infectious Disorders - Drug Targets Iron Deficiency: The Hidden Miscreant in Inflammatory Bowel Disease
Current Drug Targets Role of Biological Mediators of Tumor-Associated Macrophages in Breast Cancer Progression
Current Medicinal Chemistry Cellular Mechanisms that Edit the Immunopeptidome
Current Proteomics Targeting the Chemokine Receptor CXCR3 and Its Ligand CXCL10 in the Central Nervous System: Potential Therapy for Inflammatory Demyelinating Disease?
Current Neurovascular Research Sjogrens Syndrome and Lymphoma Development
Current Immunology Reviews (Discontinued) Anti-tumorigenic Efficacy of Tangeretin in Liver Cancer – An In Silico Approach
Current Computer-Aided Drug Design Treatment with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors to Reduce Cardiovascular Inflammation and Outcomes
Current Medicinal Chemistry Boosting Interleukin-10 Production: Therapeutic Effects and Mechanisms
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The Aging of the Adaptive Immune System
Current Immunology Reviews (Discontinued) Application of an In Vivo Brain Microdialysis Technique to Studies of Drug Transport Across the Blood-Brain Barrier
Current Drug Metabolism Endothelial Cells in Inflammation and Angiogenesis
Current Drug Targets - Inflammation & Allergy Fenofibrate: Metabolic and Pleiotropic Effects
Current Vascular Pharmacology Are Tender Point Injections Beneficial: The Role of Tonic Nociception in Fibromyalgia
Current Pharmaceutical Design