Pharmacological Properties of Furoxans and Benzofuroxans: Recent Developments

Title: Pharmacological Properties of Furoxans and Benzofuroxans: Recent Developments

Volume: 5 Issue: 1

Author(s): Hugo Cerecetto and Williams Porcal

Affiliation:

Keywords: benzofuroxans, isomerization, nmr spectroscopy, intramolecular cyclization, antibacterial

Abstract: The chemistry of furoxans (1, 2, 5-oxadiazole-2-oxides) and benzofuroxans (benzo[1, 2-c]1, 2, 5- oxadiazole-1-oxides) is very well known. These systems are widely used in organic chemistry as intermediate compounds for the synthesis of numerous heterocycles. In the other hand, furoxan and benzofuroxan derivatives were extensively studied as bioactive compounds. They possess remarkable biological activities, such as anti-microbial and anti-parasitic properties, mutagenic, immunosuppressive and anticancer effects, anti-aggregating and vasorelaxant activity, among others. In some cases, molecular mode of action was proposed. Recently, the research and development in the medicinal chemistry of these systems have produced hybrid compounds in which furoxan or benzofuroxan moieties together with a classical drug moieties are present in a single molecule. So, new anti-ulcer drugs, calcium channel modulators and vasodilator derivatives were described and they are currently in study. In this presentation recent developments in the medicinal chemistry of furoxans and benzofuroxans will be reviewed.

Cite this article as:

Cerecetto Hugo and Porcal Williams, Pharmacological Properties of Furoxans and Benzofuroxans: Recent Developments, Mini-Reviews in Medicinal Chemistry 2005; 5 (1) . https://dx.doi.org/10.2174/1389557053402864