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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Peptide-Oligonucleotide Hybrids in Antisense Therapy

Author(s): Tracie L. Pierce, Anthony R. White, Geoffrey W. Tregear and Patrick M. Sexton

Volume 5, Issue 1, 2005

Page: [41 - 55] Pages: 15

DOI: 10.2174/1389557053402846

Price: $65

Abstract

Antisense technology provides outstanding promise for treatment of human disease, having broad applicability and high specificity. Although advances have been made in antisense oligonucleotide chemistry, leading to increased plasma and cellular stability, and decreased toxicity, considerable potential remains for the enhancement of oligonucleotide uptake for targeted delivery of oligonucleotides. One promising avenue for achieving this is via linkage of antisense oligonucleotides to peptide carriers. This review looks at the current status of developments in this area.

Keywords: antisense therapy, oligonucleotides, nuclear localisation sequences


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