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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Photoaffinity Labeling of P-Glycoprotein

Author(s): Michael Peer, Edina Csaszar, Elisabeth Vorlaufer, Stephan Kopp and Peter Chiba

Volume 5, Issue 2, 2005

Page: [165 - 172] Pages: 8

DOI: 10.2174/1389557053402738

Price: $65

Abstract

The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.

Keywords: multidrug resistance, p-glycoprotein, affinity labeling


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