Abstract
At least two different types of sigma σ (σ1 and σ2) receptors have been identified. A structural feature common to high-affinity (Ki < 10 nM) σ1 ligands is: C-N(R)-X-Ph; both C and Ph are associated with regions of bulk tolerance. Numerous other ligands bind, but typically do so with lower affinity.
Keywords: sigma receptors, arylalkylamines, arylpentylamines piperazines, piperidines, pharmacophore
Mini-Reviews in Medicinal Chemistry
Title: Pharmacophore Identification for Sigma-1 (σ1) Receptor Binding: Application of the "Deconstruction - Reconstruction - Elaboration" Approach
Volume: 5 Issue: 10
Author(s): R. A. Glennon
Affiliation:
Keywords: sigma receptors, arylalkylamines, arylpentylamines piperazines, piperidines, pharmacophore
Abstract: At least two different types of sigma σ (σ1 and σ2) receptors have been identified. A structural feature common to high-affinity (Ki < 10 nM) σ1 ligands is: C-N(R)-X-Ph; both C and Ph are associated with regions of bulk tolerance. Numerous other ligands bind, but typically do so with lower affinity.
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Glennon A. R., Pharmacophore Identification for Sigma-1 (σ1) Receptor Binding: Application of the "Deconstruction - Reconstruction - Elaboration" Approach, Mini-Reviews in Medicinal Chemistry 2005; 5 (10) . https://dx.doi.org/10.2174/138955705774329519
DOI https://dx.doi.org/10.2174/138955705774329519 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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