Advances in Prodrug Design

Antonio   Tavora   de Albuquerque Silva; Man   C.   Chung; Lucia   F.   Castro; Rafael   V.   Carvalho Guido; Elizabeth   I.   Ferreira

Abstract

The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene- Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given.

Keywords: prodrug design, latent advanced systems, macromolecules carriers, selective delivery systems

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Mini-Reviews in Medicinal Chemistry

Title: Advances in Prodrug Design

Volume: 5 Issue: 10

Author(s): Antonio Tavora de Albuquerque Silva, Man C. Chung, Lucia F. Castro, Rafael V. Carvalho Guido and Elizabeth I. Ferreira

Affiliation:

Keywords: prodrug design, latent advanced systems, macromolecules carriers, selective delivery systems

Abstract: The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene- Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given.

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de Albuquerque Silva Tavora Antonio, Chung C. Man, Castro F. Lucia, Carvalho Guido V. Rafael and Ferreira I. Elizabeth, Advances in Prodrug Design, Mini-Reviews in Medicinal Chemistry 2005; 5 (10) . https://dx.doi.org/10.2174/138955705774329528

DOI https://dx.doi.org/10.2174/138955705774329528	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607

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