Abstract
A series of new peptidomimetics based on the tripeptide sequence Z-Leu-Phe-Gln-OH were synthesized, with ten of these including the α-nitrogen atom of the N-terminal amino acid incorporated into the pyrrole cycle. The synthesized compounds were tested for antiviral activity by agar-diffusion plaque inhibition test against Coxsackievirus B1 replication in FL cell. Four of the products were observed to possess an antiviral activity, which was proven to be significant for one product. N- terminal pyrrole moiety and C-terminal free carboxyl function are available in all active compounds. On the other hand, their corresponding -OBzl and -OBut esters are inactive.
Keywords: Antipicornaviral compounds, pyrroles, peptidomimetics, 3C inhibitors, Coxsackievirus, SPPS
Protein & Peptide Letters
Title: Design, Synthesis and Biological Evaluation of Antipicornaviral Pyrrole-Containing Peptidomimetics
Volume: 14 Issue: 9
Author(s): I. Minchev, S. Vladimirova, L. Vezenkov, A. Bijev, V. Moussis, L. Nikolaeva-Glomb, V. Tsikaris, M. Czeuz and A. Galabov
Affiliation:
Keywords: Antipicornaviral compounds, pyrroles, peptidomimetics, 3C inhibitors, Coxsackievirus, SPPS
Abstract: A series of new peptidomimetics based on the tripeptide sequence Z-Leu-Phe-Gln-OH were synthesized, with ten of these including the α-nitrogen atom of the N-terminal amino acid incorporated into the pyrrole cycle. The synthesized compounds were tested for antiviral activity by agar-diffusion plaque inhibition test against Coxsackievirus B1 replication in FL cell. Four of the products were observed to possess an antiviral activity, which was proven to be significant for one product. N- terminal pyrrole moiety and C-terminal free carboxyl function are available in all active compounds. On the other hand, their corresponding -OBzl and -OBut esters are inactive.
Export Options
About this article
Cite this article as:
Minchev I., Vladimirova S., Vezenkov L., Bijev A., Moussis V., Nikolaeva-Glomb L., Tsikaris V., Czeuz M. and Galabov A., Design, Synthesis and Biological Evaluation of Antipicornaviral Pyrrole-Containing Peptidomimetics, Protein & Peptide Letters 2007; 14 (9) . https://dx.doi.org/10.2174/092986607782110220
DOI https://dx.doi.org/10.2174/092986607782110220 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Comparison of Uptake Mechanisms for Anthracyclines in Human Leukemic Cells
Current Drug Delivery Hydrogen Sulfide in Diabetic Complications: Focus on Molecular Mechanisms
Endocrine, Metabolic & Immune Disorders - Drug Targets Prospects of Non-Coding Elements in Genomic DNA Based Gene Therapy
Current Gene Therapy Transient Receptor Potential (TRP) Channels and Cardiac Fibrosis
Current Topics in Medicinal Chemistry Assessment of Endothelial Function by Positron Emission Tomography
Current Cardiology Reviews Methadone and the Heart: What the Clinician Needs to Know
Current Drug Abuse Reviews Prevalence of Dilated Cardiomyopathy in HIV-Infected African Patients Not Receiving HAART: A Multicenter, Observational, Prospective, Cohort Study in Rwanda
Current HIV Research Hypertension in Hemodialysis Patients
Current Hypertension Reviews Pleiotropic Effects of Cytokines on Acute Myocardial Infarction: G-CSF as A Novel Therapy for Acute Myocardial Infarction
Current Pharmaceutical Design Ryanodine Receptor as Insecticide Target
Current Pharmaceutical Design NGS Technologies as a Turning Point in Rare Disease Research , Diagnosis and Treatment
Current Medicinal Chemistry Hypoxia and Fetal Heart Development
Current Molecular Medicine Nanoceria: Synthesis and Biomedical Applications
Current Nanoscience Morphological and Molecular Changes of the Myocardium After Left Ventricular Mechanical Support
Current Cardiology Reviews Lifestyle Changes and Surgical Treatment for Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry Cytopathological Mechanisms in Mitochondrial Disease
Current Chemical Biology The Role of PPARs in Pathological Cardiac Hypertrophy and Heart Failure
Current Pharmaceutical Design Inhibition of the Calcineurin-NFAT Signalling Cascade in the Treatment of Heart Failure
Recent Patents on Cardiovascular Drug Discovery Efficacy of Enzyme Replacement Therapy in Fabry Disease
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Statins and Oxidative Stress in the Cardiovascular System
Current Pharmaceutical Design