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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Toxic Conformation of the 42-residue Amyloid β Peptide and Its Relevance to Oxidative Stress in Alzheimers Disease

Author(s): K. Irie, K. Murakami, Y. Masuda, A. Morimoto, H. Ohigashi, H. Hara, R. Ohashi, K. Takegoshi, H. Fukuda, M. Nagao, T. Shimizu and T. Shirasawa

Volume 7, Issue 10, 2007

Page: [1001 - 1008] Pages: 8

DOI: 10.2174/138955707782110187

Price: $65

Abstract

Senile plaques in the brain of patients with Alzheimers disease mainly consist of aggregates of amyloid β peptides (Aβ42, Aβ40). Aβ42 is more neurotoxic than Aβ40. This review describes recent findings from a structural analysis of Aβ42 aggregates and discusses their relevance to neurotoxicity through the formation of radicals.

Keywords: Alzheimer's disease, amyloidβ, cerebral amyloid angiopathy, ESR, neurotoxicity, proline, oxidative stress, solidstate NMR

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