Abstract
Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and S1P leading to cell survival, proliferation and invasion. This review will examine the effects of ceramide and S1P on glioma cells and the therapeutic potential of these pathways.
Keywords: Glioma, glioblastoma multiforme, sphingolipids, sphingosine-1-phosphate, ceramide
Mini-Reviews in Medicinal Chemistry
Title: Sphingolipid Signaling Pathways as Potential Therapeutic Targets in Gliomas
Volume: 7 Issue: 10
Author(s): James R. Van Brocklyn
Affiliation:
Keywords: Glioma, glioblastoma multiforme, sphingolipids, sphingosine-1-phosphate, ceramide
Abstract: Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The interconvertible bioactive sphingolipids sphingosine-1-phosphate (S1P) and ceramide have profound effects on GBM cells, with ceramide causing cell death and S1P leading to cell survival, proliferation and invasion. This review will examine the effects of ceramide and S1P on glioma cells and the therapeutic potential of these pathways.
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Cite this article as:
Van Brocklyn R. James, Sphingolipid Signaling Pathways as Potential Therapeutic Targets in Gliomas, Mini-Reviews in Medicinal Chemistry 2007; 7 (10) . https://dx.doi.org/10.2174/138955707782110123
DOI https://dx.doi.org/10.2174/138955707782110123 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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