Artemisinin Delays Sphingolipid Biosynthesis in Plasmodium falciparum

Title: Artemisinin Delays Sphingolipid Biosynthesis in Plasmodium falciparum

Volume: 4 Issue: 7

Author(s): Francoise Debierre-Grockiego, Jorg Schmidt, Eliezer Flescher and Ralph T. Schwarz

Affiliation:

Keywords: Plasmodium, Artemisinin, Serine, Ceramide, Sphingomyelin

Abstract: Artemisinin induces the growth inhibition of Plasmodium falciparum by sphingomyelinase-generated ceramide. To understand whether artemisinin could have another effect, sphingolipid biosynthesis was studied. Our result shows that a delay in the formation of final products (globoside, cerebrosides) production might be involved in the increase of ceramide.

Cite this article as:

Debierre-Grockiego Francoise, Schmidt Jorg, Flescher Eliezer and Schwarz T. Ralph, Artemisinin Delays Sphingolipid Biosynthesis in Plasmodium falciparum, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788499