Abstract
IL-10 is an anti-inflammatory cytokine widely regarded as an inhibitor of immunity. Thus IL-10 and IL-10 antagonist have been proposed as promising therapeutic factors for the treatment of inflammatory diseases and pathogen infections. Here the potential risk of favoring secondary pathogen infections with these therapies is underscored.
Keywords: IL-10, IL-10 antagonists, Immunotherapy
Letters in Drug Design & Discovery
Title: Caveats Regarding the Use of IL-10 and IL-10 Antagonist as Immunotherapeutic Factors
Volume: 4 Issue: 7
Author(s): Jesus Colino
Affiliation:
Keywords: IL-10, IL-10 antagonists, Immunotherapy
Abstract: IL-10 is an anti-inflammatory cytokine widely regarded as an inhibitor of immunity. Thus IL-10 and IL-10 antagonist have been proposed as promising therapeutic factors for the treatment of inflammatory diseases and pathogen infections. Here the potential risk of favoring secondary pathogen infections with these therapies is underscored.
Export Options
About this article
Cite this article as:
Colino Jesus, Caveats Regarding the Use of IL-10 and IL-10 Antagonist as Immunotherapeutic Factors, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788552
DOI https://dx.doi.org/10.2174/157018007781788552 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
CX-4945, a Selective Inhibitor of Casein Kinase 2, Synergizes with B Cell Receptor Signaling Inhibitors in Inducing Diffuse Large B Cell Lymphoma Cell Death
Current Cancer Drug Targets Monoclonal Antibodies: A New Era in the Treatment of Non-Hodgkins Lymphoma
Current Pharmaceutical Biotechnology Detection of the Incidence of Infections and Acute Biochemical Changes in Diffused Large B-Cell Lymphoma Patients Treated with Cyclophosphamide, Doxorubicin, Vincristine and Prednisone (CHOP) with and without Rituximab
Current Drug Safety It is All About Proteases: From Drug Delivery to In Vivo Imaging and Photomedicine
Current Medicinal Chemistry Radiolabeled RGD Peptides as Integrin alpha(v)beta3–targeted PET Tracers
Current Medicinal Chemistry Review on Documented Medicinal Plants used for the Treatment of Cancer
Current Traditional Medicine Neuroimmune Crosstalk in CNS Disorders: The Histamine Connection
Current Pharmaceutical Design Dendritoma Vaccine for Cancer: A Hopeful Approach
Current Cancer Therapy Reviews De Novo Malignancies After Organ Transplantation: Focus on Viral Infections
Current Molecular Medicine Base Excision Repair, the Redox Environment and Therapeutic Implications
Current Molecular Pharmacology Pharmaceutical Targeting of the Brain
Current Pharmaceutical Design <i>Rhizoma Coptidis</i> for Alzheimer’s Disease and Vascular Dementia: A Literature Review
Current Vascular Pharmacology Nutlins and Ionizing Radiation in Cancer Therapy
Current Pharmaceutical Design The Enzymology of Cytosolic Pyrimidine 5’-Nucleotidases: Functional Analysis and Physiopathological Implications.
Current Medicinal Chemistry Non-Genotoxic p53-Activators and their Significance as Antitumor Therapy of Future
Current Medicinal Chemistry Oxidative Stress in Atherosclerosis Development: The Central Role of LDL and Oxidative Burst
Endocrine, Metabolic & Immune Disorders - Drug Targets Antineoplastic Action of Growth Hormone-Releasing Hormone (GHRH) Antagonists
Recent Patents on Anti-Cancer Drug Discovery Retrovirus Translation Initiation: Issues and Hypotheses Derived from Study of HIV-1
Current HIV Research An Updated Patent Therapeutic Agents Targeting MMPs
Recent Patents on Anti-Cancer Drug Discovery Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery
Mini-Reviews in Medicinal Chemistry