Abstract
We report the preliminary results into the synthesis and evaluation of triazole-based compounds against the components of 17α-hydroxylase/17,20-lyase (P45017α), namely 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase). The results show that the compounds are weaker than ketoconazole but are good lead compounds in the search for inhibitors of P45017α, in particular, lyase.
Keywords: 17α-hydroxylase, 17,20-lyase, P45017α, Synthesis, Evaluation, Triazole
Letters in Drug Design & Discovery
Title: Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Series of 4-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of 17α-Hydroxylase/17,20-Lyase (P45017α)
Volume: 4 Issue: 7
Author(s): Caroline P. Owen, Sachin Dhanani, Chirag H. Patel and Sabbir Ahmed
Affiliation:
Keywords: 17α-hydroxylase, 17,20-lyase, P45017α, Synthesis, Evaluation, Triazole
Abstract: We report the preliminary results into the synthesis and evaluation of triazole-based compounds against the components of 17α-hydroxylase/17,20-lyase (P45017α), namely 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase). The results show that the compounds are weaker than ketoconazole but are good lead compounds in the search for inhibitors of P45017α, in particular, lyase.
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Cite this article as:
Owen P. Caroline, Dhanani Sachin, Patel H. Chirag and Ahmed Sabbir, Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Series of 4-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of 17α-Hydroxylase/17,20-Lyase (P45017α), Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788471
DOI https://dx.doi.org/10.2174/157018007781788471 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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