Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents

Title: Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents

Volume: 4 Issue: 7

Author(s): Romeo Romagnoli, Pier Giovanni Baraldi, Olga Cruz Lopez, Maria Dora Carrion, Carlota Lopez Cara, Delia Preti, Mojgan Aghazadeh Tabrizi and Jan Balzarini

Affiliation:

Keywords: Microwave, Thiazole, Anticancer agents

Abstract: The microwave-promoted cyclization method has been used for the synthesis of a series of novel substituted 2,4-diarylthiazoles from α-halo ketones and thioamides using ethanol as solvent. This rapid method produces compounds in good yield within one minute in comparison with conventional heating method. The synthesized molecules have been evaluated for their antiproliferative effects against five different cancer cell lines.

Cite this article as:

Romagnoli Romeo, Baraldi Giovanni Pier, Lopez Cruz Olga, Carrion Dora Maria, Cara Lopez Carlota, Preti Delia, Tabrizi Aghazadeh Mojgan and Balzarini Jan, Microwave-Assisted Synthesis of Substituted 2,4-Diarylthiazoles and their Evaluation as Anticancer Agents, Letters in Drug Design & Discovery 2007; 4 (7) . https://dx.doi.org/10.2174/157018007781788507