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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Contribution of Analytical Microscopies to Human Neurodegenerative Diseases Research (PSP and AD)

Author(s): Carmen Quintana

Volume 7, Issue 9, 2007

Page: [961 - 975] Pages: 15

DOI: 10.2174/138955707781662654

Price: $65

Abstract

Using analytical microscopies we have observed an increase of Fe2+ iron-induced oxidative stress inside pathological ferritin (Ft). This finding, together with the presence of Ft in myelinated axons associated with oligodendrocyte processes and myelin sheet fraying, suggests that a dysfunction of ferritin (a ferritinopathy) may be the non-specific agingdependent pathogenic event responsible for neurodegenerative disease.

Keywords: Ferritinopathy, neuropathology, alzheimer, analytical microscopies, nanoSIMS


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