Abstract
PrTX-I, a non-catalytic and myotoxic Lys49-PLA2 from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), α-tocopherol and α-tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 Å resolution. All complexes crystals are isomorphous and belong to the space group P21 whereas native PrTX-I crystals belong to the P3121.
Keywords: Crystallization, X-ray crystallography, Lys49-phospholipase A2, Bothrops pirajai venom, myotoxity, pbromophenacyl bromide, p-BPB, α-tocopherol, vitamin E
Protein & Peptide Letters
Title: Preliminary X-Ray Crystallographic Studies of a Lys49-Phospholipase A2 Homologue from Bothrops pirajai Venom Complexed with p-Bromophenacyl Bromide and α-Tocopherol Inhibitors
Volume: 14 Issue: 7
Author(s): Juliana I. dos Santos, Daniela P. Marchi-Salvador, Carlos A.H. Fernandes, Lucas B. Silveira, Andreimar M. Soares and Marcos R.M. Fontes
Affiliation:
Keywords: Crystallization, X-ray crystallography, Lys49-phospholipase A2, Bothrops pirajai venom, myotoxity, pbromophenacyl bromide, p-BPB, α-tocopherol, vitamin E
Abstract: PrTX-I, a non-catalytic and myotoxic Lys49-PLA2 from Bothrops pirajai venom has been crystallized alone and in complex with bromophenacyl bromide (BPB), α-tocopherol and α-tocopherol acetate inhibitors. These crystals have shown to diffract X-rays between 2.34 and 1.65 Å resolution. All complexes crystals are isomorphous and belong to the space group P21 whereas native PrTX-I crystals belong to the P3121.
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Juliana I. dos Santos , Daniela P. Marchi-Salvador , Carlos A.H. Fernandes , Lucas B. Silveira , Andreimar M. Soares and Marcos R.M. Fontes , Preliminary X-Ray Crystallographic Studies of a Lys49-Phospholipase A2 Homologue from Bothrops pirajai Venom Complexed with p-Bromophenacyl Bromide and α-Tocopherol Inhibitors, Protein & Peptide Letters 2007; 14 (7) . https://dx.doi.org/10.2174/092986607781483796
DOI https://dx.doi.org/10.2174/092986607781483796 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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