Pigment Epithelium-Derived Factor (PEDF) Inhibits Angiotensin IIInduced Smooth Muscle Cell Proliferation Through Its Anti-Oxidative Properties

Title: Pigment Epithelium-Derived Factor (PEDF) Inhibits Angiotensin IIInduced Smooth Muscle Cell Proliferation Through Its Anti-Oxidative Properties

Volume: 14 Issue: 6

Author(s): Sho-ichi Yamagishi, Takanori Matsui, Kazuo Nakamura and Tsutomu Imaizumi

Affiliation:

Keywords: Angiotensin II, atherosclerosis, oxidative stress, PEDF

Abstract: Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis, suggesting that loss of this factor may be involved in angiogenic eye disease. Here, we show that PEDF inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties. Our present study suggests that PEDF may play a protective role against atherosclerosis.

Cite this article as:

Sho-ichi Yamagishi , Takanori Matsui , Kazuo Nakamura and Tsutomu Imaizumi , Pigment Epithelium-Derived Factor (PEDF) Inhibits Angiotensin IIInduced Smooth Muscle Cell Proliferation Through Its Anti-Oxidative Properties, Protein & Peptide Letters 2007; 14 (6) . https://dx.doi.org/10.2174/092986607780989976