Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease

Title: Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease

Volume: 4 Issue: 5

Author(s): Leonardo G. Ferreira, Andrei Leitao, Carlos A. Montanari and Adriano D. Andricopulo

Affiliation:

Keywords: HIV, AIDS, Enzyme Inhibitors, QSAR, HQSAR

Abstract: HIV-specific protease inhibitors are fundamental antiviral drugs for people with HIV/AIDS. Hologram quantitative structure-activity relationships (HQSAR) were conducted on a class of 82 protease inhibitors. The final model obtained was used to predict the potency of 17 test set compounds. The predicted values were in good agreement with the experimental results.

Cite this article as:

Ferreira G. Leonardo, Leitao Andrei, Montanari A. Carlos and Andricopulo D. Adriano, Hologram Quantitative Structure-Activity Relationships for a Class of Inhibitors of HIV-1 Protease, Letters in Drug Design & Discovery 2007; 4 (5) . https://dx.doi.org/10.2174/157018007780867825