Synthesis of Novel 5,6,7-Substituted 3-Phenyl-6,7-Dihydroisoxazolo[4,5-d]Pyrimidines

Title: Synthesis of Novel 5,6,7-Substituted 3-Phenyl-6,7-Dihydroisoxazolo[4,5-d]Pyrimidines

Volume: 4 Issue: 3

Author(s): S. B. Aliabiev, I. S. Ivanov, A. P. Ilyin, D. V. Kravchenko and A. V. Ivachtchenko

Affiliation:

Keywords: Cyclization, heterocycle, isoxazolo[4,5-d]pyrimidine, amines, carboxamides, library

Abstract: In this work we present a convenient synthetic route to novel 5,6,7-substituted 3-phenyl-6,7-dihydroisoxazolo[ 4,5-d]pyrimidines. The key synthetic step is based on the cyclization of 4-amino-3- phenylisoxazole-5-carboxamides and ethyl 4-[(ethoxymethylene)amino]-3-phenylisoxazole-5-carboxylates. The developed methodology can be easily adapted to high-throughput combinatorial format.

Cite this article as:

Aliabiev B. S., Ivanov S. I., Ilyin P. A., Kravchenko V. D. and Ivachtchenko V. A., Synthesis of Novel 5,6,7-Substituted 3-Phenyl-6,7-Dihydroisoxazolo[4,5-d]Pyrimidines, Letters in Organic Chemistry 2007; 4 (3) . https://dx.doi.org/10.2174/157017807780737318