New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide

Title: New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide

Volume: 4 Issue: 3

Author(s): Bing Liu, Cao Fang, Zhi-Bing Dong and Jin-Shan Li

Affiliation:

Keywords: BINOL, Schiff base, diethylzinc, asymmetric addition, titanium

Abstract: We have developed three new chiral 3-substituted BINOL Schiff base ligands for the asymmetric diethylzinc addition to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active second alcohols in high yield and moderate enantioselectivity (up to 67% ee).

Cite this article as:

Liu Bing, Fang Cao, Dong Zhi-Bing and Li Jin-Shan, New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide, Letters in Organic Chemistry 2007; 4 (3) . https://dx.doi.org/10.2174/157017807780737327