Abstract
The antimicrobial activity of two cationic liposomes containing three antibiotics were tested in vitro. Ciprofloxacin loaded in liposomes exhibited a 2-4 times higher antimicrobial activity compared with the free drug. The bacterial sensitivity to liposomal meropenem were similar as to free antibiotic. The least effective were the liposomes containing gentamicin.
Keywords: Liposomes, Meropenem, Gentamicin, Ciprofloxacin, Bacteria
Letters in Drug Design & Discovery
Title: In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains
Volume: 4 Issue: 4
Author(s): Jerzy Gubernator, Zuzanna Drulis-Kawa, Agata Dorotkiewicz-Jach, Wlodzimierz Doroszkiewicz and Arkadiusz Kozubek
Affiliation:
Keywords: Liposomes, Meropenem, Gentamicin, Ciprofloxacin, Bacteria
Abstract: The antimicrobial activity of two cationic liposomes containing three antibiotics were tested in vitro. Ciprofloxacin loaded in liposomes exhibited a 2-4 times higher antimicrobial activity compared with the free drug. The bacterial sensitivity to liposomal meropenem were similar as to free antibiotic. The least effective were the liposomes containing gentamicin.
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Cite this article as:
Gubernator Jerzy, Drulis-Kawa Zuzanna, Dorotkiewicz-Jach Agata, Doroszkiewicz Wlodzimierz and Kozubek Arkadiusz, In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620040
DOI https://dx.doi.org/10.2174/157018007784620040 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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