Abstract
Human embryonic stem cells (hESCs) can be propagated as undifferentiated cells over multiple passages and thus offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Because of the important roles of dopaminergic (DA) neurons in modulating motor control, and in particular that the selective degeneration of DA neurons in midbrain cause the neurodegenerative disorder Parkinsons disease (PD), there has been significant interest in using hESC-derived DA neurons as a source of cells for drug screening, discovery and transplant purposes. Different strategies have evolved to generate appropriately mature DA neurons that have been purified and/or enriched by one of several selection techniques. In this manuscript we discuss recent results, review the remarkable progress that has been made in the field, and compare these results with those obtained from mouse ESCs (mESCs).
Keywords: Parkinson's disease, ubiquitin, Human embryonic stem cells, Neural Progenitors, Transplantation
Current Stem Cell Research & Therapy
Title: Generation and Transplantation of Dopaminergic Neurons Derived from Embryonic Stem Cells
Volume: 2 Issue: 2
Author(s): Aparna Khanna, Anna Maria Swistowska, Mahendra S. Rao and Xianmin Zeng
Affiliation:
Keywords: Parkinson's disease, ubiquitin, Human embryonic stem cells, Neural Progenitors, Transplantation
Abstract: Human embryonic stem cells (hESCs) can be propagated as undifferentiated cells over multiple passages and thus offer a renewable source of a wide range of cell types for use in research and cell-based therapies. Because of the important roles of dopaminergic (DA) neurons in modulating motor control, and in particular that the selective degeneration of DA neurons in midbrain cause the neurodegenerative disorder Parkinsons disease (PD), there has been significant interest in using hESC-derived DA neurons as a source of cells for drug screening, discovery and transplant purposes. Different strategies have evolved to generate appropriately mature DA neurons that have been purified and/or enriched by one of several selection techniques. In this manuscript we discuss recent results, review the remarkable progress that has been made in the field, and compare these results with those obtained from mouse ESCs (mESCs).
Export Options
About this article
Cite this article as:
Khanna Aparna, Maria Swistowska Anna, Rao S. Mahendra and Zeng Xianmin, Generation and Transplantation of Dopaminergic Neurons Derived from Embryonic Stem Cells, Current Stem Cell Research & Therapy 2007; 2 (2) . https://dx.doi.org/10.2174/157488807780599266
DOI https://dx.doi.org/10.2174/157488807780599266 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Regulation of Apo E Expression by the Nuclear Receptors- LXRs and FXR
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Anti-Inflammatory Activity of Novel 12-N-methylcytisine Derivatives
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Conformational Diseases and ER Stress-Mediated Cell Death: Apoptotic Cell Death and Autophagic Cell Death
Current Molecular Medicine Improving Brain Drug Targeting Through Exploitation of The Nose-to- Brain Route: A Physiological and Pharmacokinetic Perspective
Current Drug Delivery Gene Therapy for Parkinsons Disease: Progress and Challenges
Current Gene Therapy Role of Morin in Neurodegenerative Diseases: A Review
Current Topics in Medicinal Chemistry Epigenetics in Alzheimers Disease: a Focus on DNA Modifications
Current Pharmaceutical Design Competitive Interaction Between Plasma Omega-3 Fatty Acids and Arachidonic Acid is Related to Down-Regulation of A Signaling Mediator
Medicinal Chemistry Editorial (Hot Topic:Therapeutic Agents of Lipids and Fatty Acids)
Current Organic Chemistry Metal-Score as a Potential Non-Invasive Diagnostic Test for Alzheimer’s Disease
Current Alzheimer Research Alzheimer’s Disease and Parkinson’s Disease: A Review of Current Treatment Adopting a Nanotechnology Approach
Current Pharmaceutical Design Mechanism of CNS Drugs and their Combinations for Alzheimers Disease
Central Nervous System Agents in Medicinal Chemistry Neuronal Death and Survival Under Oxidative Stress in Alzheimer and Parkinson Diseases
CNS & Neurological Disorders - Drug Targets Oxidative DNA Damage and Oxidant/Anti-Oxidant Enzymatic Systems in Carcinogenesis and Cancer Progression
Current Enzyme Inhibition Preface
Current Molecular Medicine The Paths to Neurodegeneration in Genetic Parkinson's Disease
CNS & Neurological Disorders - Drug Targets Human Lipoxygenase: Developments in its Structure, Function, Relevance to Diseases and Challenges in Drug Development
Current Medicinal Chemistry Protective Effects of Chronic Green Tea Consumption on Age-related Neurodegeneration
Current Pharmaceutical Design Nutraceutical: A Drug, Dietary Supplement and Food Ingredient
Current Pharmacogenomics and Personalized Medicine A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders
Current Alzheimer Research