Abstract
Indoles are abundant in nature, and exhibit important biological properties such as anti-inflammatory, antihypertensive, dopaminergic, antineoplastic, anticonvulsant, analgesic, sedative, muscle relaxant, and antimicrobial activities. Synthesis, and functionalization of pharmacologically active indoles continue to receive considerable attention in the field of synthetic organic chemistry. Recent advances toward synthesis of natural, and unnatural indoles have been accelerated by transition metal catalysts, and in the context rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations with quite often-unique selectivity. This review describes the formation of indoles via rhodium catalyzed C-H, and X-H insertion (X = N, O, and S), cycloaddition, hydroformylation, bimetallic, and asymmetric hydrogenation reactions. Use of solid phase chemistry in rhodium catalyzed indole synthesis has also been discussed in the article.
Keywords: Indoles, Rhodium(II)-catalyst, Insertion, Cycloaddition, Hydrogination, Solid-phase
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
7