Abstract
Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme( s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates.
Keywords: Bothrops jararaca, ATP-pyrophosphatase, ATPase, ADPase, Phosphodiesterase, 5'-nucleotidase
Protein & Peptide Letters
Title: Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis
Volume: 14 Issue: 4
Author(s): Andre Teixeira-Ferreira and Elias Walter Alves
Affiliation:
Keywords: Bothrops jararaca, ATP-pyrophosphatase, ATPase, ADPase, Phosphodiesterase, 5'-nucleotidase
Abstract: Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme( s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates.
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Cite this article as:
Teixeira-Ferreira Andre and Walter Alves Elias, Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis, Protein & Peptide Letters 2007; 14 (4) . https://dx.doi.org/10.2174/092986607780363998
DOI https://dx.doi.org/10.2174/092986607780363998 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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Protein & Peptide Letters