A Short C-Terminal Region of Alpha-Synuclein Protects a (R/S)-Nonspecific Esterase from Archaeglobus fulgidus

Title: A Short C-Terminal Region of Alpha-Synuclein Protects a (R/S)-Nonspecific Esterase from Archaeglobus fulgidus

Volume: 14 Issue: 4

Author(s): SeungBum Kim, Mira Kang, Yeonwoo Ryu and T. Doohun Kim

Affiliation:

Keywords: α-Synuclein, esterase, protective activity, molecular engineering

Abstract: We show that α-synuclein could assist the molecular activity of a ketoprofen-(R/S) nonspecific esterase from Archaeglobus Fulgidus. Specifically, several synthetic peptides from α-synuclein, each having random coil conformation in far-UV spectra, could protect the enzyme activity against stress conditions such as heat and organic solvents.

Cite this article as:

Kim SeungBum, Kang Mira, Ryu Yeonwoo and Doohun Kim T., A Short C-Terminal Region of Alpha-Synuclein Protects a (R/S)-Nonspecific Esterase from Archaeglobus fulgidus, Protein & Peptide Letters 2007; 14 (4) . https://dx.doi.org/10.2174/092986607780363880