Gestational Programming of Offspring Obesity: A Potential Contributor to Alzheimers Disease

Michael   G.   Ross; Mina      Desai; Omid      Khorram; Robert   A.   McKnight; Robert   H.   Lane; John      Torday

Abstract

Obesity and its related diseases are the leading cause of death in western society, with associated risks of hypertension, coronary heart disease, stroke, diabetes, and breast, prostate and colon cancer. Recent epidemiologic data indicate an increased risk of Alzheimers disease in association with adult obesity. There is now convincing evidence that, in both human and animal models, the in utero environment may impact on fetal developmental processes, altering offspring homeostatic regulatory mechanisms. “Gestational programming” may result in altered cell number, organ structure, hormonal set points or gene expression, with effects being permanent or expressed only at select offspring ages (e.g., newborn, adult). Our laboratory and others have demonstrated that low birth weight rats, induced by maternal food restriction or uterine artery ligation, paradoxically develop adult obesity with glucose intolerance and hypertension. Recent studies indicate alterations in peripheral (hepatic) and central (hippocampus) IGF-1 gene expression and epigenetic regulation among these offspring. These findings suggest that potential risk factors for the development of Alzheimers disease may be present as early as newborn life.

Keywords: Metabolic syndrome, gestational programming, epigenetic, fetal development, obesity, Alzheimer, IGF-1, leptin