Abstract
Novel compounds have been developed that (in many cases) inhibit cholinesterases and concomitantly interact with at least one further pharmacological target, such as 5-HT3 or H3 receptors. But also enzymes like monoamine oxidase and the serotonin transporter have been targeted. Hybrid molecules can also incorporate antioxidant or neuronal Ca2+- channel-blocking structures.
Keywords: Hybrid molecules, Multiple ligands, AChE inhibitors, Serotonin transporter (SERT), monoamine oxidase (MAO), lipoic acid, 5-HT3 receptor, Ca2+-channel blockers
Mini-Reviews in Medicinal Chemistry
Title: Recent Advances in the Development of Hybrid Molecules/Designed Multiple Compounds with Antiamnesic Properties
Volume: 7 Issue: 3
Author(s): Michael Decker
Affiliation:
Keywords: Hybrid molecules, Multiple ligands, AChE inhibitors, Serotonin transporter (SERT), monoamine oxidase (MAO), lipoic acid, 5-HT3 receptor, Ca2+-channel blockers
Abstract: Novel compounds have been developed that (in many cases) inhibit cholinesterases and concomitantly interact with at least one further pharmacological target, such as 5-HT3 or H3 receptors. But also enzymes like monoamine oxidase and the serotonin transporter have been targeted. Hybrid molecules can also incorporate antioxidant or neuronal Ca2+- channel-blocking structures.
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Cite this article as:
Decker Michael, Recent Advances in the Development of Hybrid Molecules/Designed Multiple Compounds with Antiamnesic Properties, Mini-Reviews in Medicinal Chemistry 2007; 7 (3) . https://dx.doi.org/10.2174/138955707780059817
DOI https://dx.doi.org/10.2174/138955707780059817 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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