Abstract
In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ETAh and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6- trimethylphenyl)benzamide (23) was the most interesting.
Keywords: Hypertension, Endothelins, G protein-coupled receptors, ET receptors, Benzenesulfonamides, Binding properties
Letters in Drug Design & Discovery
Title: Synthesis and Binding Properties of New Endothelin Receptor Ligands
Volume: 4 Issue: 3
Author(s): Maria Modica, Loredana Salerno, Valeria Pittala, Giuseppe Romeo, Mariangela Siracusa, Ilario Mereghetti, Alfredo Cagnotto and Tiziana Mennini
Affiliation:
Keywords: Hypertension, Endothelins, G protein-coupled receptors, ET receptors, Benzenesulfonamides, Binding properties
Abstract: In this paper we report the synthesis of a new series of benzenesulfonamides and the evaluation of their binding properties on ETAh and ETBh receptor subtypes. Some new derivatives behave as selective ETAh receptor ligands and among them, 2-{[(4-chloro-3-methyl-5-isoxazolyl)amino]sulfonyl}-N-(2,4,6- trimethylphenyl)benzamide (23) was the most interesting.
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Cite this article as:
Modica Maria, Salerno Loredana, Pittala Valeria, Romeo Giuseppe, Siracusa Mariangela, Mereghetti Ilario, Cagnotto Alfredo and Mennini Tiziana, Synthesis and Binding Properties of New Endothelin Receptor Ligands, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077426
DOI https://dx.doi.org/10.2174/157018007780077426 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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