Abstract
(-)-Epigallocatechin gallate (EGCG) has a sedative effect acting through γ-aminobutyric acid (GABA)A receptors in the brain, but it is unclear what structural components of the molecule are necessary for its action. To investigate the necessity of the galloyl group on the sedation induced by EGCG, the effect of EGCG was compared with (-)-epigallocatechin (EGC) in which the galloyl group is removed from EGCG. Intracerebroventricular (i.c.v.) injection of EGC, as well as EGCG, induced, and the effect of EGC were blocked by the GABAA receptor antagonist picrotoxin. It is concluded that catechins have a sedative effect acting through GABAA receptors under an acute stress condition irrespective of the presence of the galloyl group.
Keywords: (-)-Epigallocatechin gallate, (-)-Epigallocatechin, γ-Aminobutyric acid receptors, Brain, Intracerebroventricular injection, Chick
Letters in Drug Design & Discovery
Title: Galloyl Group is not Necessary for a Sedative Effect of Catechin Through GABAergic System
Volume: 4 Issue: 3
Author(s): Nami Adachi, Shozo Tomonaga, Rie Suenaga, D. Michael Denbow and Mitsuhiro Furuse
Affiliation:
Keywords: (-)-Epigallocatechin gallate, (-)-Epigallocatechin, γ-Aminobutyric acid receptors, Brain, Intracerebroventricular injection, Chick
Abstract: (-)-Epigallocatechin gallate (EGCG) has a sedative effect acting through γ-aminobutyric acid (GABA)A receptors in the brain, but it is unclear what structural components of the molecule are necessary for its action. To investigate the necessity of the galloyl group on the sedation induced by EGCG, the effect of EGCG was compared with (-)-epigallocatechin (EGC) in which the galloyl group is removed from EGCG. Intracerebroventricular (i.c.v.) injection of EGC, as well as EGCG, induced, and the effect of EGC were blocked by the GABAA receptor antagonist picrotoxin. It is concluded that catechins have a sedative effect acting through GABAA receptors under an acute stress condition irrespective of the presence of the galloyl group.
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Cite this article as:
Adachi Nami, Tomonaga Shozo, Suenaga Rie, Michael Denbow D. and Furuse Mitsuhiro, Galloyl Group is not Necessary for a Sedative Effect of Catechin Through GABAergic System, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077444
DOI https://dx.doi.org/10.2174/157018007780077444 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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