Enantioselective Synthesis of 2,3-Disubstituted Piperidines

Title: Enantioselective Synthesis of 2,3-Disubstituted Piperidines

Volume: 4 Issue: 1

Author(s): Michael Calosso, Mathieu Wagner, Thomas Gendrineau, Morgane Petit, Catherine Kadouri-Puchot and Luc Dechoux

Affiliation:

Keywords: Asymmetric synthesis, pipecolic acids, piperidines, phenylglycinol, aza-annelation

Abstract: Chiral derivative 3 has been recognized as a precursor of enantiopure 2,3-disubstituted piperidines. A study concerning the chemoselective reduction, using BH3.Me2S, of highly functionalised compounds 6 and N-BOC aminoacid 12 is reported.

Cite this article as:

Calosso Michael, Wagner Mathieu, Gendrineau Thomas, Petit Morgane, Kadouri-Puchot Catherine and Dechoux Luc, Enantioselective Synthesis of 2,3-Disubstituted Piperidines, Letters in Organic Chemistry 2007; 4 (1) . https://dx.doi.org/10.2174/157017807780037487