Abstract
Phosphodiesterases are clinical targets for congestive heart failure, erectile dysfunction and inflammation. Intake of carotenoids decreases the risk of cardiovascular and inflammatory diseases. Therefore, phosphodiesterase binding of the carotenoid derivative disodium disuccinate astaxanthin (Cardax) was investigated using molecular modeling methods. Cardax was predicted to bind to PDE5A at the catalytic site.
Keywords: Astaxanthin, Cardax, Carotenoids, Disodium disuccinate astaxanthin, Docking, Phosphodiesterase 5A
Letters in Drug Design & Discovery
Title: Non-Covalent Binding of Disodium Disuccinate Astaxanthin to the Catalytic Site of Phosphodiesterase 5A: A Molecular Modeling Study
Volume: 4 Issue: 2
Author(s): Eszter Hazai, Zsolt Bikadi, Ferenc Zsila and Samuel F. Lockwood
Affiliation:
Keywords: Astaxanthin, Cardax, Carotenoids, Disodium disuccinate astaxanthin, Docking, Phosphodiesterase 5A
Abstract: Phosphodiesterases are clinical targets for congestive heart failure, erectile dysfunction and inflammation. Intake of carotenoids decreases the risk of cardiovascular and inflammatory diseases. Therefore, phosphodiesterase binding of the carotenoid derivative disodium disuccinate astaxanthin (Cardax) was investigated using molecular modeling methods. Cardax was predicted to bind to PDE5A at the catalytic site.
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Cite this article as:
Hazai Eszter, Bikadi Zsolt, Zsila Ferenc and Lockwood F. Samuel, Non-Covalent Binding of Disodium Disuccinate Astaxanthin to the Catalytic Site of Phosphodiesterase 5A: A Molecular Modeling Study, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422497
DOI https://dx.doi.org/10.2174/157018007779422497 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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