Abstract
The Na+-HCO3 - symport plays as significant role as the Na+/H+ exchanger in ischemia/reperfusion injury. Under bicarbonate free conditions, however, the Na+-HCO3 - symport does not work, and so the protective efficacy of Na+/H+ exchanger inhibitors is overestimated. We discuss the reasons for the inconsistencies in studies of the Na+/H+ exchanger.
Keywords: Na+/H+ exchanger, Review, Human, Surgery, Cariporide, Eniporide
Letters in Drug Design & Discovery
Title: Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application
Volume: 4 Issue: 1
Author(s): Yasuyuki Shimada and Fumio Yamamoto
Affiliation:
Keywords: Na+/H+ exchanger, Review, Human, Surgery, Cariporide, Eniporide
Abstract: The Na+-HCO3 - symport plays as significant role as the Na+/H+ exchanger in ischemia/reperfusion injury. Under bicarbonate free conditions, however, the Na+-HCO3 - symport does not work, and so the protective efficacy of Na+/H+ exchanger inhibitors is overestimated. We discuss the reasons for the inconsistencies in studies of the Na+/H+ exchanger.
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Cite this article as:
Shimada Yasuyuki and Yamamoto Fumio, Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application, Letters in Drug Design & Discovery 2007; 4 (1) . https://dx.doi.org/10.2174/157018007778992838
DOI https://dx.doi.org/10.2174/157018007778992838 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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