Abstract
Novel biomarker identification and drug target validation are highly complex and resource-intensive processes, requiring an integral use of various tools, approaches and information. The recently developed proteomic technology features high-throughput parallel analysis of thousands of proteins in individual patients and amount populations and thus opens up the possibility of providing more details at a global level on the molecular mechanisms. With regularly updated public databases, bioinformatics can contribute to these processes by providing functional information of target candidates and correlating this information to the biological pathways. In this review, we outline recent advances of bioinformatic application in proteomic research on biomarker discovery and drug target validation. Specifically, we highlight how bioinformatics can facilitate the proteomic studies of biomarker identification and drug target validation.
Keywords: Bioinformatics, biomarker discovery, drug design, drug development, proteomics
Current Bioinformatics
Title: Bioinformatic Application in Proteomic Research on Biomarker Discovery and Drug Target Validation
Volume: 2 Issue: 1
Author(s): Ying Wang, Jen-Fu Chiu and Qing-Yu He
Affiliation:
Keywords: Bioinformatics, biomarker discovery, drug design, drug development, proteomics
Abstract: Novel biomarker identification and drug target validation are highly complex and resource-intensive processes, requiring an integral use of various tools, approaches and information. The recently developed proteomic technology features high-throughput parallel analysis of thousands of proteins in individual patients and amount populations and thus opens up the possibility of providing more details at a global level on the molecular mechanisms. With regularly updated public databases, bioinformatics can contribute to these processes by providing functional information of target candidates and correlating this information to the biological pathways. In this review, we outline recent advances of bioinformatic application in proteomic research on biomarker discovery and drug target validation. Specifically, we highlight how bioinformatics can facilitate the proteomic studies of biomarker identification and drug target validation.
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Cite this article as:
Wang Ying, Chiu Jen-Fu and He Qing-Yu, Bioinformatic Application in Proteomic Research on Biomarker Discovery and Drug Target Validation, Current Bioinformatics 2007; 2 (1) . https://dx.doi.org/10.2174/157489307779314294
DOI https://dx.doi.org/10.2174/157489307779314294 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
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