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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Convenient Synthesis of α-Amino Acid-Derived Cyclic Amides for Use as Building Blocks for Protease Inhibitors

Author(s): Maxim E. Sergeev and Tatiana L. Voyushina

Volume 3, Issue 11, 2006

Page: [857 - 860] Pages: 4

DOI: 10.2174/157017806779117102

Price: $65

Abstract

An efficient and straightforward approach towards the synthesis of a-amino acid-derived cyclic amides was developed. A series of cyclic amides of various natural amino acids were obtained in excellent yields under mild conditions. The obtained compounds could be efficiently used as ligands for affinity chromatography of enzymes.

Keywords: Amino acids, amides, enzymes, inhibitors, affinity chromatography


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