Abstract
Historical progress in medicine can be charted along the lines of technical innovations that have visualized the invisible. One hundred years ago, Alois Alzheimer exploited newly developed histological stains to visualize his eponymonous disease in dead tissue under the microscope. Now, as we are entering the second century of Alzheimers disease research, technical innovation has endowed us with a range of in vivo imaging techniques that promise to visualize Alzheimer disease in living people. The earliest stage of Alzheimers disease is characterized by cell-sickness, not cell-death, and can occur before the deposition of amyloid plaques or neurofibrillary tangles. In principle, functional imaging techniques might be able to detect this early stage of the disease, a stage that was invisible to Alzheimer himself. Here, we will first define the neurobiological meaning of function and then review the different approaches that measure brain dysfunction in Alzheimer disease.
Keywords: Cerebral Blood Flow, SPECT, Deoxyhemoglobin, Glucose Uptake, synaptic strength, MRI
Current Alzheimer Research
Title: Imaging the Earliest Stages of Alzheimers Disease
Volume: 3 Issue: 5
Author(s): William Wu and Scott A. Small
Affiliation:
Keywords: Cerebral Blood Flow, SPECT, Deoxyhemoglobin, Glucose Uptake, synaptic strength, MRI
Abstract: Historical progress in medicine can be charted along the lines of technical innovations that have visualized the invisible. One hundred years ago, Alois Alzheimer exploited newly developed histological stains to visualize his eponymonous disease in dead tissue under the microscope. Now, as we are entering the second century of Alzheimers disease research, technical innovation has endowed us with a range of in vivo imaging techniques that promise to visualize Alzheimer disease in living people. The earliest stage of Alzheimers disease is characterized by cell-sickness, not cell-death, and can occur before the deposition of amyloid plaques or neurofibrillary tangles. In principle, functional imaging techniques might be able to detect this early stage of the disease, a stage that was invisible to Alzheimer himself. Here, we will first define the neurobiological meaning of function and then review the different approaches that measure brain dysfunction in Alzheimer disease.
Export Options
About this article
Cite this article as:
Wu William and Small A. Scott, Imaging the Earliest Stages of Alzheimers Disease, Current Alzheimer Research 2006; 3 (5) . https://dx.doi.org/10.2174/156720506779025161
DOI https://dx.doi.org/10.2174/156720506779025161 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Clinical Characteristics of Behcet’s Disease in 453 Egyptian Patients Suffering from Uveitis with Gender Comparison
Current Rheumatology Reviews Novel Targets for the Development of Anti-Herpes Compounds
Infectious Disorders - Drug Targets Activation and Control of CNS Innate Immune Responses in Health and Diseases: A Balancing Act Finely Tuned by Neuroimmune Regulators (NIReg)
CNS & Neurological Disorders - Drug Targets Inflammatory Cytokines in Acute Ischemic Stroke
Current Pharmaceutical Design Synthesis, Antimicrobial Evaluation and Docking Study of Novel Thiosemicarbazone Clubbed with 1,2,3-Triazoles
Current Bioactive Compounds Update on Childhood Brucellosis
Recent Patents on Anti-Infective Drug Discovery The Methylerythritol Phosphate Pathway and its Significance as a Novel Drug Target
Current Pharmaceutical Biotechnology Tuberculosis Infections of the Central Nervous System
Central Nervous System Agents in Medicinal Chemistry Subdural Pharmacotherapy for the Treatment of Intractable Focal Neocortical Epilepsy
Drug Delivery Letters Fluorinated Molecules as Drugs and Imaging Agents in the CNS
Current Topics in Medicinal Chemistry Lung Cancer Chemotherapy, New Treatment and Related Patents
Recent Patents on Anti-Cancer Drug Discovery Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder
Current Medicinal Chemistry Drug Targeting to the Brain - A Review
Current Nanoscience Neuroimaging of Non-Accidental Injury
Current Pediatric Reviews Research Advances in Neuroblastoma Immunotherapy
Current Pediatric Reviews subject Index To Volume 1
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Organic Lesions in the Brain MRI of Children with Febrile Seizure
Current Medical Imaging Clinical Applications of Choline PET/CT in Brain Tumors
Current Pharmaceutical Design Community-Acquired Pneumonia in Children
Recent Patents on Inflammation & Allergy Drug Discovery Therapeutic Implications of Tocilizumab, A Humanized Anti-Interleukin-6 Receptor Antibody, for Various Immune-Mediated Diseases: An Update Review
Current Rheumatology Reviews