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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Blockade of Chemokine-Mediated Tissue Injury in Lupus Nephritis

Author(s): Volker Vielhauer and Hans-Joachim Anders

Volume 6, Issue 4, 2006

Page: [313 - 321] Pages: 9

DOI: 10.2174/187153006779025739

Price: $65

Abstract

Pro-inflammatory chemokines are important mediators of inflammation and autoimmune injury. The spatial and temporal expression of chemokines and chemokine receptors in the nephritic kidney suggests that targeting the chemokine system may represent a valuable approach for anti-inflammatory therapy of lupus nephritis. In this review we summarize the available data on the pathogenic role of chemokines and chemokine receptors in lupus nephritis and particularly focus on epidemiological data in lupus patients and interventional studies with chemokine or chemokine receptor antagonists in experimental lupus.

Keywords: Chemokine, chemokine receptors, systemic lupus erythematosus, MRL/lpr mouse, leukocyte recruitment, kidney, polymorphism


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