An Asymmetric Synthesis of the β-Hydroxy Acid Segment of Hapalosin (EXPERIMENTAL)

Title: An Asymmetric Synthesis of the β-Hydroxy Acid Segment of Hapalosin (EXPERIMENTAL)

Volume: 3 Issue: 10

Author(s): Anubha Sharma, Siddharth Roy, Dibakar Goswami, Angshuman Chattopadhyay and Subrata Chattopadhyay

Affiliation:

Keywords: Asymmetric synthesis, (R)-cyclohexylideneglyceraldehyde, hapalosin, β-hydroxy acid

Abstract: A facile synthesis of the title compound has been developed starting from the crotylated product of (R)-cyclohexylideneglyceraldehyde (2). The key features of the synthesis were stereochemical control of the crotylation by alteration of reaction conditions, operational simplicity and the use of inexpensive compounds/reagents.

Cite this article as:

Sharma Anubha, Roy Siddharth, Goswami Dibakar, Chattopadhyay Angshuman and Chattopadhyay Subrata, An Asymmetric Synthesis of the β-Hydroxy Acid Segment of Hapalosin (EXPERIMENTAL), Letters in Organic Chemistry 2006; 3 (10) . https://dx.doi.org/10.2174/157017806779025997