New Insights into the Regulation of Liver Inflammation and Oxidative Stress

Natalia      Ferre; Joan      Claria

Abstract

Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.

Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species

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