Abstract
Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.
Keywords: Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics
Mini-Reviews in Medicinal Chemistry
Title: Carbohydrate-Based Scaffolds in Drug Discovery
Volume: 6 Issue: 12
Author(s): Bernd Becker, Glenn C. Condie, Giang Thanh Le and Wim Meutermans
Affiliation:
Keywords: Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics
Abstract: Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.
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Cite this article as:
Becker Bernd, Condie C. Glenn, Thanh Le Giang and Meutermans Wim, Carbohydrate-Based Scaffolds in Drug Discovery, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778993003
DOI https://dx.doi.org/10.2174/138955706778993003 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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